Filtered By:
Cancer: Colorectal Cancer

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 40091 results found since Jan 2013.

Lessons from a systematic literature search on diagnostic DNA methylation biomarkers for colorectal cancer: how to increase research value and decrease research waste
DiscussionThis systematic literature search revealed that major requirements to develop clinically relevant diagnostic CRC DNA methylation markers are often lacking. To avoid the resulting research waste, clinical needs, intended biomarker use and independent validation should be better considered prior to study design. In addition, improved reporting quality would facilitate meta-analysis, thereby increasing level of evidence and enabling clinical translation.PMID:35584320 | DOI:10.14309/ctg.0000000000000499
Source: Clinical Colorectal Cancer - May 18, 2022 Category: Cancer & Oncology Authors: Zheng Feng Cary J G Oberije Alouisa J P van de Wetering Alexander Koch Kim A D Wouters Nathalie Vaes Ad A M Masclee Beatriz Carvalho Gerrit A Meijer Maurice P Zeegers James G Herman Veerle Melotte Manon van Engeland Kim M Smits Source Type: research

Relationship Between State-Level Google Online Search Volume and Cancer Incidence in the United States: Retrospective Study
Conclusions: Cancer incidence is correlated with online search volume at the state level. Search patterns were temporally associated with cancer awareness months and celebrity announcements. Online searches reflect public awareness. Advancing understanding of online search patterns could augment traditional epidemiologic surveillance, provide opportunities for targeted patient engagement, and allow public information campaigns to be evaluated in ways previously unable to be measured.
Source: Journal of Medical Internet Research - January 8, 2018 Category: General Medicine Authors: Charles A. Phillips Allison Barz Leahy Yimei Li Marilyn M. Schapira L. Charles Bailey Raina M. Merchant Source Type: research

The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patie...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis
ConclusionsOur search for the POEs of present IEs was often successful, as was searching for an oral or dental or a gastrointestinal POE of a new IE episode. We advise the systematic performance of stomatologic examinations in patients with IE and performance of colonoscopy in patients ≥50 years of age or at high risk for colorectal cancer.
Source: Journal of the American College of Cardiology - January 12, 2016 Category: Cardiology Source Type: research

Abstract 5555: Pharmacogenetics-pharmacokinetics study of bevacizumab in mCRC patients treated with Avastin-Folfiri regimen: Search for predictive markers of response and study of the pharmacokinetics variability
Identifying biomarkers predictive of response is a rising trend in clinical oncology, especially when administrating costly targeted therapies and biologics. Unlike other monoclonal antibodies such as cetuximab, panitumumab, trastuzumab or ipilimumab, search for genetic or molecular makers predictive for clinical outcome with widely prescribed bevacizumab has failed to generate consensual results over the last decade. We have performed a pilot study in 70 patients with metastatic colorectal cancer receiving the standard bevacizumab-Folfiri protocol. More specifically, our study focused on the retrospective screening of the...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Chantry, A.-S., Ciccolini, J., Sibertin-Blanc, C., Dahan, L., Olschwang, S., Seitz, J., Lacarelle, B. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract CT211: Biomarker search using gene expression databases in a phase III controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene expression level
Conclusions: Location, differentiation and depth of the tumor correlated with each gene expressions. Our findings will facilitate understanding the characteristics of colon cancer. Further investigation on gene expressions including genome-wide copy number analysis may contribute to the exploration of valid biomarkers.Citation Format: Hiroyuki Uetake, Toshiaki Ishikawa, Megimi Ishiguro, Shigeyuki Matsui. Biomarker search using gene expression databases in a phase III controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gen...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Uetake, H., Ishikawa, T., Ishiguro, M., Matsui, S. Tags: Clinical Trials Source Type: research

Role of "Second Look" Lymph Node Search in Harvesting Optimal Number of Lymph Nodes for Staging of Colorectal Carcinoma.
Authors: Hamza A, Sakhi R, Khawar S, Alrajjal A, Edens J, Khurram MS, Khan U, Szpunar S, Mazzara P Abstract As with other malignancies, lymph node metastasis is an important staging element and prognostic factor in colorectal carcinomas. The number of involved lymph nodes is directly related to decreased 5-year overall survival for all pT stages according to United States Surveillance, Epidemiology, and End Results (SEER) cancer registry database. The National Quality Forum specifies that the presence of at least 12 lymph nodes in a surgical resection is one of the key quality measures for the evaluation of colorec...
Source: Gastroenterology Research and Practice - May 31, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Cancers, Vol. 12, Pages 3311: Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers
a Ferreira Vidal Vivian Nogueira Silbiger Ândrea Ribeiro-dos-Santos The aberrant expression of microRNAs in known to play a crucial role in carcinogenesis. Here, we evaluated the miRNA expression profile of sigmoid colon cancer (SCC) compared to adjacent-to-tumor (ADJ) and sigmoid colon healthy (SCH) tissues obtained from colon biopsy extracted from Brazilian patients. Comparisons were performed between each group separately, considering as significant p-values < 0.05 and |Log2(Fold-Change)| > 2. We found 20 differentially expressed miRNAs (DEmiRNAs) in all comparisons, two of which were shar...
Source: Cancers - November 10, 2020 Category: Cancer & Oncology Authors: Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Ana Beatriz Bezerra-Oliveira Romualdo da Silva Correa Carlos Cesar de Oliveira Ramos Tatiana Vinasco-Sandoval Katia de Paiva Lopes Ricardo Assun ção Vialle Amanda Ferreira Vidal V Tags: Article Source Type: research

Cancers, Vol. 15, Pages 4245: Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers
rnero Élez Microsatellite instability (MSI) is a biological condition associated with inflamed tumors, high tumor mutational burden (TMB), and responses to immune checkpoint inhibitors. In colorectal cancer (CRC), MSI tumors are found in 5% of patients in the metastatic setting and 15% in early-stage disease. Following the impressive clinical activity of immune checkpoint inhibitors in the metastatic setting, associated with deep and long-lasting responses, the development of immune checkpoint inhibitors has expanded to early-stage disease. Several phase II trials have demonstrated a high rate of pathological compl...
Source: Cancers - August 24, 2023 Category: Cancer & Oncology Authors: Ros Baraibar Saoudi Rodriguez Salv à Tabernero Élez Tags: Review Source Type: research

Nitric oxide and cancer: a review
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration. NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On ...
Source: World Journal of Surgical Oncology - May 30, 2013 Category: Cancer & Oncology Authors: Sheetal Korde ChoudhariMinal ChaudharySachin BagdeAmol GadbailVaishali Joshi Source Type: research

Pre-analytical-related variability influencing serum peptide profiles demonstrated in a mass spectrometry-based search for colorectal and prostate cancer biomarkers.
Abstract Although the degradome, which comprises proteolytic fragments of blood proteins, presents a potential source of diagnostic biomarkers, studies on cancer peptide biomarkers have provided inconsistent conclusions. In the present study, we reevaluated the usefulness of serum degradome analyses for searching peptide cancer biomarker candidates. Particular attention was paid to pre-analytical factors influencing the variability of determined peptide levels, including clotting time and control group selection. Studies were conducted on 44 and 86 serum samples collected from cancer patients and healthy individua...
Source: Acta Biochim Pol - September 18, 2013 Category: Biochemistry Authors: Karczmarski J, Rubel T, Mikula M, Wolski J, Rutkowski A, Zagorowicz E, Dadlez M, Ostrowski J Tags: Acta Biochim Pol Source Type: research

New approaches but the same flaws in the search of prognostic signatures.
Abstract A six-gene prognostic colorectal cancer hypoxia score was generated from expression data from in vitro experiments and microarray datasets and was validated in two distinct patient cohorts. The approach followed by the authors is original and biologically sound but could be limited by potential biases and other methodological limitations. PMID: 24583802 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - February 28, 2014 Category: Cancer & Oncology Authors: Salazar R, Tabernero J Tags: Clin Cancer Res Source Type: research

Colorectal carcinomas in 2013: The search for powerful prognostic markers is still on the go!
Abstract Colorectal cancer (CRC) is the third cause of cancer worldwide after prostate cancer and breast cancer. Patients have a survival rate of 5 years, which varies between 10 and 95% depending on the CRC stage. Today, the management of patients with CRC is based on parameters such as TNM and classic histologic parameters, but new molecular and cell markers have been created to improve treatment and survival. Determining the expression of a characteristic set of genes either from formalin-fixed paraffin-embedded tissues (Onco type DX test™) or from fresh tissues (AGENDIA© ColoPrint®) has led to encouraging ...
Source: Cancer Biomarkers : Section A of Disease Markers - January 1, 2014 Category: Cancer & Oncology Authors: Coget J, Borrini F, Susman S, Sabourin JC Tags: Cancer Biomark Source Type: research

Abstract 283: Biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (acts-cc): Correlation between gene expression and DNA copy number
Background: The ACTS-CC trial is a randomized, controlled phase III study designed to validate the noninferiority of S-1 to UFT/LV as adjuvant chemotherapy for stage III colon cancer and rectosigmoid cancer. A prospective biomarker search was performed as an auxiliary study of the ACTS-CC trial, using formalin-fixed, paraffin-embedded (FFPE) specimens obtained from 892 patients. The gene expression levels of 5-FU metabolizing enzymes and folate metabolizing enzymes and alterations of genome-wide copy numbers in tumor have been reported (2012 and 2013 Annual Meetings of AACR). In the present study, we performed correlation ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Uetake, H., Ishikawa, T., Ishiguro, M., Matsui, S., Sugihara, K., ACTS-CC Study Group Tags: Clinical Research (Excluding Clinical Trials) Source Type: research